epiSAMe (S-adenosine Methionine) is a chemical compound found naturally in the body.

It is the most important methyl donor in the body.

epiSAMe is a nutritional supplement that promotes optimal hormone levels and therefore affect human health.



What is epiSAMe?

The level of epiSAMe decreases as the body ages. Concomitantly, a number of health issues, including mood, joined, and liver disorders are likely to occur​.

All SAM-e molecules have two forms: the SS (active) isomer and the RS (inactive) isomer.

While epiSAMe comes in two stable salt forms; tosylate and butane disulphonate, only the tosylate form is backed by twenty years of research for safety and effectiveness.

Why Chose epiSAMe

  • Manufactured to the highest standards, using the original
    Italian method (salt - tosylate disulfate)
  • SAMe products’ starting raw materials consistently
    test at the highest SS to RS isomer ratio on the market:
    SS isomer >80% / RS isomer <20%.
  • Enteric coated for optimum absorption by the body
  • Sealed in blister packs to ensure freshness
  • Made to guaranteed purity and potency standards: No Artifical Flavors, Dairy Free, No Preservatives, Allergen Free, No Yeast or Gluten, Kosher Certified
  • Have been tested for a minimum full two year stability rating
  • Feed us with your health and lifestyle information
    to establish your personalized health ecosystem

In the Spotlight


From the literature:

SAM-e has been shown to improve mood & emotional well being, joint health, comfort & mobility and healthy liver function in clinical studies.

In March of 2003, the AHRQ (Agency for Healthcare Research and Quality) a division of the United States Health and Human Services, released the findings of a major study on SAM-e.

SAM-e is as effective as conventional prescription medications in the treatment of depression.

SAM-e is as effective as standard prescription medications (NSAIDs) in the treatment of osteoarthritis.

SAM-e has significant benefits for patients suffering from various liver diseases. Natural SAM-e was not found to have any noticeable side effects.

Basic research on SAM-e on human cell lines and animals which were not yet followed by clinical studies